Noted Herbalist Discusses the Active Mechanisms of Swiss Medica’s (OTC BB: SWME) O24
Vertolli was a member of Health Canada’s advisory panel on natural health products (Canada’s equivalent of the U.S. Food and Drug Administration). He believes there are constituents within the O24
Take for example carnosol, which is a naturally occurring phytopolyphenol found in rosemary. In a study published in the June 2002 issue of Carcinogenesis, biochemists researching anticarcinogenic properties at the College of Medicine’s Institute of Biochemistry at National Taiwan University found that carnosol may suppress nitric oxide production. That may help explain the anti-inflammatory action of the rosemary essential oil component in O24
According to the American Chemical Society, which recently named the 1,8-cineole its “Molecule of the Week,” there may be a scientific reason why the O24
An entire class of anti-inflammatory drugs has come into this culture in an effort to numb chronic pain by inhibiting the synthesis of prostaglandin. Over the past few months, it has come to the general public’s attention that this method of remedying chronic pain can be deadly, i.e. the solution is worse than the problem. “Most people look upon inflammation as if it is something bad,” said Vertolli. “Like every physiological response, it has a purpose. Inflammation is an integral part of the healing process. If we apply a product that simply interferes with inflammation, it is going to interfere with healing as well. With O24
What Vertolli may be suggesting is that a functional solution for most people suffering from pain may have been right under their noses throughout the twentieth century to this present day: essential oils. What are essential oils? They are not the same as perfume or fragrance oils, some of which are artificially created or contain artificial substances. Essential oils contain the true essence of the plant from which the oil is derived. Often, an essential oil does not have an oily feeling because it is a liquid generally distilled from a plant’s leaves, stems, flowers, bark or roots. Essential oils are highly concentrated and a little goes a long way.
Mr. Vertolli cited key components within O24
Other important constituents include camphor (white camphor, eucalyptus, rosemary), pinene (eucalyptus, rosemary, white camphor), menthol (peppermint, white camphor), limonene (lemon, sweet orange, eucalyptus, rosemary, peppermint), menthone (peppermint), carnosol (rosemary), linalool (sweet orange, rosemary, lemon), geraniol (sweet orange, lemon), anthraquinone glycosides (aloe), and dozens of others.
Not a Placebo
Components within the essential oils have long been recognized to alleviate pain. Some people might wonder whether the benefits of O24
Scientifically, there are molecular reasons why components within O24
Salicyclates, on the other hand, inhibit prostaglandin and thromboxane release. As with all non-steroidal anti-inflammatory drugs, they bring about an analgesic impact on the body when topically applied. They work in the same way as aspirin does and attempt to provide a similar relief from pain, but on a topical level.
Both tend to give all topical pain relievers a bad name. With the addition of mineral oils, creams, paraffin or other additives (water, alcohol, glycerin or another binding agent), its pain-relieving properties can be diluted. This tends to explain why the scientific community denigrates topicals as an effective solution to pain. Medical doctors shy away from the general body of topical analgesics because relief is fleeting, or lead their patients to believe it is a “placebo effect.”
Yet various forms of vapor rubs, to relieve the pains of congested chests and sinuses, have sold throughout the world for decades. Such brand names, or their generics, have been doctor recommended for as long a time. Many have active ingredients that include camphor, eucalyptus oil and menthol and carry the phrase, topical analgesic, on their labels.
How do these differ from the O24
The dramatic impact O24
Inhibiting Prostaglandin and Thromboxane Synthesis
There are specific components within the essential oils, which parallel the actions of non-steroidal anti-inflammatories. This requires a brief overview of how aspirin, aspirin-like drugs (such as the class of COX-1 inhibitors: ibuprofen, naproxen) and the COX-2 inhibitors (generically the coxibs sold as brand names: Vioxx®, Celebrex® and Bextra®) impact the body.
Those with arthritis or rheumatism may be familiar with prostaglandins. These are pain mediators in the human body, and are found in nearly all tissues and organs. Prostaglandins are hormone-like substances, a group of lipid compounds derived from fatty acids. They are produced from a precursor molecule called arachidonic acid by cyclooxygenases (COX-1 and COX-2). The arachidonic acid pathway is one of the main pain- and inflammation-producing mechanisms. Not only are the prostaglandins produced, but so are thromboxane and the leukotrienes (which cause asthma symptoms). While prostaglandins participate in the contraction and relaxation of smooth muscles, the dilation and contraction of blood vessels, the control of blood pressure and the modulation of inflammation, thromboxane (A2) is involved in the constriction of vascular and respiratory smooth muscles.
Discovered in 1971 that aspirin and other non-steroidal anti-inflammatories could inhibit the enzyme cyclooxygenase, biochemist Sir John Vane and his colleagues won the 1982 Nobel Prize in Medicine. Their research demonstrated that the potency of the anti-inflammatory medicines were proportional to how well they performed as COX-1 inhibitors. But, they also discovered that cyclooxygenase inhibition led to toxic side effects: non-steroidal anti-inflammatories cause erosive gastritis and renal toxicity.
“Wonder drugs,” such as celecoxib and rofecoxib, were designed to prevent gastric bleeding (gastric bleeding reportedly causes more than 16,000 deaths annually and has been called a “silent epidemic”). The COX-2 inhibitors are said to interfere with the prostaglandin production process. This restraining action is what made COX-2 inhibitors popular. By hindering prostaglandin synthesis, someone in chronic pain was able to alleviate his or her suffering. Unfortunately, because of the recent controversy surrounding the COX-2 class, such as Vioxx®, Celebrex® and Bextra®, many arthritis sufferers have returned to the COX-1 inhibitors (gastric bleeding that reportedly results in more than 100,000 hospitalizations annually). Common COX-1 inhibitors are probably found in your medicine cabinet: ibuprofen, naproxen and aspirin.
In Vertolli’s research into why O24
Vertolli is very enthusiastic about the rosemary essential oil in O24
Finally, Vertolli returns to cineole, which he calls a “fairly strong constituent” and is found in white camphor, eucalyptus, rosemary and peppermint. Vertolli also writes, “I specifically focused on the analgesic, anti-inflammatory, relaxant and antispasmodic properties because that is what the product is being used for. I am confident you would find that O24